Tumour-derived transforming growth factor-β signalling contributes to fibrosis in patients with cancer cachexia.

ABSTRACT:

Background

Cachexia is a paraneoplastic syndrome related with poor prognosis. The tumour micro-environment contributes to systemic inflammation and increased oxidative stress as well as to fibrosis. The aim of the present study was to characterise the inflammatory circulating factors and tumour micro-environment profile, as potentially contributing to tumour fibrosis in cachectic cancer patients.

Methods

74 patients (weight stable cancer n = 31; cachectic cancer n = 43) diagnosed with colorectal cancer were recruited, and tumour biopsies were collected during surgery. Multiplex assay was performed to study inflammatory cytokines and growth factors. Immunohistochemistry analysis was carried out to study extracellular matrix components.

Results

Higher protein expression

SUBMITTER: Lima JDCC 

PROVIDER: S-EPMC6818454 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature