Traumatic Brain Injury Temporal Proteome Guides KCC2-Targeted Therapy.

ABSTRACT: Advancing therapeutics for traumatic brain injury (TBI) remains a challenge, necessitating testable targets with interventions appropriately timed to intercede on evolving secondary insults. Neuroproteomics provides a global molecular approach to deduce the complex post-translational processes that underlie secondary events after TBI. Yet method advancement has outpaced approaches to interrogate neuroproteomic complexity, in particular when addressing the well-recognized temporal evolution of TBI pathobiology. Presented is a detailed account of the temporal neuroproteomic response to mild-moderate rat controlled cortical impact within perilesioned somatosensory neocortex across the first two weeks after injury. Further, this investigation assessed use of artificial neural network and funct

SUBMITTER: Lizhnyak PN 

PROVIDER: S-EPMC6818491 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature