Macrophages protect against loss of adipose tissue during cancer cachexia.

ABSTRACT:

Background

Cancer cachexia represents a central obstacle in medical oncology as it is associated with poor therapy response and reduced overall survival. Systemic inflammation is considered to be a key driver of cancer cachexia; however, clinical studies with anti-inflammatory drugs failed to show distinct cachexia-inhibiting effects. To address this contradiction, we investigated the functional importance of innate immune cells for hepatocellular carcinoma (HCC)-associated cachexia.

Methods

A transgenic HCC mouse model was intercrossed with mice harbouring a defect in myeloid cell-mediated inflammation. Body composition of mice was analysed via nuclear magnetic resonance spectroscopy and microcomputed tomography. Quantitative PCR was used to determine adipose tissue brownin

SUBMITTER: Erdem M 

PROVIDER: S-EPMC6818538 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature