Hb I: A α-globin chain variant causing unexpected HbA_1c results.

ABSTRACT:

Background

HbA_1c is the standard bio-marker for glycemic control in patients with diabetes. Here, we report a α-globin chain variant and evaluate its effect on HbA_1c measurements.

Methods

A 21-year-old female was suspected of harboring a hemoglobin variant following HbA_1c measurement during a routine examination using Variant II Turbo 2.0 (Bio-Rad). An oral glucose tolerance test was performed using an AU5800 clinical chemistry system (Beckman Coulter). HbA_1c was reanalyzed using D10 (Bio-Rad), Capillarys 2 Flex Piercing (Sebia), and Premier Hb9210 (Trinity Biotech). Hemoglobin analysis was performed using high-performance liquid chromatography (HPLC) on the Bio-Rad Variant II (β-thalassemia short program) and capillary electrophor

SUBMITTER: Xu A 

PROVIDER: S-EPMC6818576 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature