Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension.

ABSTRACT:

Background

Serine hydroxymethyltransferase 1 (SHMT1) is an enzyme involved in folic acid metabolism and is known to contribute to the development of hypertension. We evaluated the relationship between SHMT1 promoter methylation and essential hypertension (EH).

Methods

Quantitative methylation-specific polymerase chain reaction was used to measure the SHMT1 promoter methylation level in 241 EH patients and 288 age- and gender-matched healthy individuals. The diagnostic value of SHMT1 promoter hypermethylation was analyzed using a receiver operating characteristic (ROC) curve. The Gene Expression Omnibus (GEO) database and dual-luciferase reporter assay were used to validate our findings.

Results

Compared with the control group, significant differences in SHMT1 promoter

SUBMITTER: Xu G 

PROVIDER: S-EPMC6818578 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature