Influence of alpha thalassemia on clinical and laboratory parameters among nigerian children with sickle cell anemia.

ABSTRACT:

Background

There is paucity of data on the influence of alpha thalassemia on the clinical and laboratory parameters among Nigerian sickle cell anemia (SCA) patients. This study aimed to determine the prevalence of alpha thalassemia and the influence of alpha thalassemia on laboratory parameters and clinical manifestations in a group of young Nigerian SCA patients.

Methods

This was a cross-sectional retrospective study conducted on 100 patients with SCA and 63 controls. The diagnosis of SCA was confirmed by DNA studies. Alpha thalassemia genotyping was performed by multiplex gap-PCR method. Laboratory parameters including complete blood count, hemoglobin quantitation, serum lactate dehydrogenase (LDH), and bilirubin were determined with standard techniques.

Results

Alp

SUBMITTER: Olatunya OS 

PROVIDER: S-EPMC6818585 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature