Longitudinal engagement trajectories and risk of death among new ART starters in Zambia: A group-based multi-trajectory analysis.

ABSTRACT: BACKGROUND:Retention in HIV treatment must be improved to advance the HIV response, but research to characterize gaps in retention has focused on estimates from single time points and population-level averages. These approaches do not assess the engagement patterns of individual patients over time and fail to account for both their dynamic nature and the heterogeneity between patients. We apply group-based trajectory analysis-a special application of latent class analysis to longitudinal data-among new antiretroviral therapy (ART) starters in Zambia to identify groups defined by engagement patterns over time and to assess their association with mortality. METHODS AND FINDINGS:We analyzed a cohort of HIV-infected adults who newly started ART between August 1, 2013, and February 1, 2015, acr

SUBMITTER: Mody A 

PROVIDER: S-EPMC6818762 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature