Increased rate of FEV1 decline in HIV patients despite effective treatment with HAART.

ABSTRACT: INTRODUCTION:Previous studies have reported that the rate of FEV1 decline over time is increased in HIV patients but the mechanisms underlying this observation are unclear. Since current HIV treatment with Highly Active Antiretroviral Therapy (HAART) results in very good immune-viral control, we hypothesized that HAART should normalize the elevated rate of FEV1 decline previously reported in HIV patients if it was somehow related to the immune alterations caused by HIV, particularly in never smokers or quitters, since smoking is a well established risk factor for accelerated FEV1 decline in the general population. METHODS:We explored this hypothesis in a prospectively recruited cohort of 188 HIV (smoker and non-smoker) patients treated with HAART in Palma de Mallorca (Spain) and followed-u

SUBMITTER: Samperiz G 

PROVIDER: S-EPMC6818778 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature