Surfactant delivery in rat lungs: Comparing 3D geometrical simulation model with experimental instillation.

ABSTRACT: Surfactant Replacement Therapy (SRT), which involves instillation of a liquid-surfactant mixture directly into the lung airway tree, is a major therapeutic treatment in neonatal patients with respiratory distress syndrome (RDS). This procedure has proved to be remarkably effective in premature newborns, inducing a five-fold decrease of mortality in the past 35 years. Disappointingly, its use in adults for treating acute respiratory distress syndrome (ARDS) experienced initial success followed by failures. Our recently developed numerical model has demonstrated that transition from success to failure of SRT in adults could, in fact, have a fluid mechanical origin that is potentially reversible. Here, we present the first numerical simulations of surfactant delivery into a realistic asymmetr

SUBMITTER: Kazemi A 

PROVIDER: S-EPMC6818804 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature