Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites.

ABSTRACT: Accurate and reliable quantification of brain metabolites measured in vivo using ¹H magnetic resonance spectroscopy (MRS) is a topic of continued interest. Aside from differences in the basic approach to quantification, the quantification of metabolite data acquired at different sites and on different platforms poses an additional methodological challenge. In this study, spectrally edited γ-aminobutyric acid (GABA) MRS data were analyzed and GABA levels were quantified relative to an internal tissue water reference. Data from 284 volunteers scanned across 25 research sites were collected using GABA+ (GABA + co-edited macromolecules (MM)) and MM-suppressed GABA editing. The unsuppressed water signal from the volume of interest was acquired for concentration referencing. Whole-bra

SUBMITTER: Mikkelsen M 

PROVIDER: S-EPMC6818968 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature