Antibody responses to viral infections: a structural perspective across three different enveloped viruses.

ABSTRACT: Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved through the dual role of antibodies in communicating the presence of invading pathogens in infected cells to effector cells, and in interfering with processes essential to the viral life cycle (chiefly entry into the host cell). For individuals that successfully control infection, virus-elicited antibodies can provide lifelong surveillance and protection from future insults. One approach to understand the nature of a successful immune response has been to utilize structural biology to uncover the molecular details of antibodies derived from vaccines or natural infection and how they interact with their cognate microbial antigens. The ability to isolate antigen-specific B-cells and rapidly solv

SUBMITTER: Murin CD 

PROVIDER: S-EPMC6818971 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature