Microgels produced using microfluidic on-chip polymer blending for controlled released of VEGF encoding lentivectors.

ABSTRACT: Alginate hydrogels are widely used as delivery vehicles due to their ability to encapsulate and release a wide range of cargos in a gentle and biocompatible manner. The release of encapsulated therapeutic cargos can be promoted or stunted by adjusting the hydrogel physiochemical properties. However, the release from such systems is often skewed towards burst-release or lengthy retention. To address this, we hypothesized that the overall magnitude of burst release could be adjusted by combining microgels with distinct properties and release behavior. Microgel suspensions were generated using a process we have termed on-chip polymer blending to yield composite suspensions of a range of microgel formulations. In this manner, we studied how alginate percentage and degradation relate to the rel

SUBMITTER: Madrigal JL 

PROVIDER: S-EPMC6819130 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature