Site of extranodal metastasis impacts survival in patients with testicular germ cell tumors.

ABSTRACT:

Background

Using a large, nationally representative, population-based cancer registry, this study systematically evaluated the impact of the location and burden of extranodal testicular germ cell tumor (TGCT) metastases on survival.

Methods

Men with stage III TGCTs captured by the Surveillance, Epidemiology, and End Results registry from 2010 to 2015 with distant extranodal metastases were identified. Clinicopathologic information was collected, and patients were subdivided according to the specific organ site or sites of metastatic involvement (lung, liver, bone, and/or brain). Kaplan-Meier analysis and multivariable Cox regression were used to evaluate cancer-specific survival (CSS), and model performance was assessed with Harrell's C statistic.

Results

Nine hundred

SUBMITTER: Patel HD 

PROVIDER: S-EPMC6819223 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature