Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to N⁶ -cyclohexyladenosine-induced hibernation in the Arctic ground squirrel (Urocitellus parryii).

ABSTRACT: Hibernation is a seasonal phenomenon characterized by a drop in metabolic rate and body temperature. Adenosine A₁ receptor agonists promote hibernation in different mammalian species, and the understanding of the mechanism inducing hibernation will inform clinical strategies to manipulate metabolic demand that are fundamental to conditions such as obesity, metabolic syndrome, and therapeutic hypothermia. Adenosine A₁ receptor agonist-induced hibernation in Arctic ground squirrels is regulated by an endogenous circannual (seasonal) rhythm. This study aims to identify the neuronal mechanism underlying the seasonal difference in response to the adenosine A₁ receptor agonist. Arctic ground squirrels were implanted with body temperature transmitters and housed a

SUBMITTER: Frare C 

PROVIDER: S-EPMC6819227 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature