Atherogenesis in the Carotid Artery with and without Interrupted Blood Flow of Two Hyperlipidemic Mouse Strains.

ABSTRACT:

Purpose

Atherosclerosis in the carotid arteries is a common cause of ischemic stroke. We examined atherogenesis in the left carotid artery with and without interrupted blood flow of C57BL/6 (B6) and C3H-Apoe-deficient (Apoe-/-) mouse strains.

Methods

Blood flow was interrupted by ligating the common carotid artery near its bifurcation in one group of mice and another group was not interrupted.

Results

Without interference with blood flow, C3H-Apoe-/- mice developed no atherosclerosis in the carotid artery, while B6-Apoe-/- mice formed advanced atherosclerotic lesions (98,019 ± 10,594 μm2/section) after 12 weeks of a Western diet. When blood flow was interrupted by ligating the common carotid artery near its bifurcation, C3H-Apoe-/- mice showed fatty streak lesions 2 w

SUBMITTER: Zhao J 

PROVIDER: S-EPMC6819243 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature