Identifying inter-individual differences in pain threshold using brain connectome: a test-retest reproducible study.

ABSTRACT: Individuals are unique in terms of brain and behavior. Some are very sensitive to pain, while others have a high tolerance. However, how inter-individual intrinsic differences in the brain are related to pain is unknown. Here, we performed longitudinal test-retest analyses to investigate pain threshold variability among individuals using a resting-state fMRI brain connectome. Twenty-four healthy subjects who received four MRI sessions separated by at least 7 days were included in the data analysis. Subjects' pain thresholds were measured using two modalities of experimental pain (heat and pressure) on two different locations (heat pain: leg and arm; pressure pain: leg and thumbnail). Behavioral results showed strong inter-individual variability and strong within-individual stability in pai

SUBMITTER: Tu Y 

PROVIDER: S-EPMC6819259 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature