Complex Phenotypes: Mechanisms Underlying Variation in Human Stature.

ABSTRACT:

Purpose of review

The goal of the review is to provide a comprehensive overview of the current understanding of the mechanisms underlying variation in human stature.

Recent findings

Human height is an anthropometric trait that varies considerably within human populations as well as across the globe. Historically, much research focus was placed on understanding the biology of growth plate chondrocytes and how modifications to core chondrocyte proliferation and differentiation pathways potentially shaped height attainment in normal as well as pathological contexts. Recently, much progress has been made to improve our understanding regarding the mechanisms underlying the normal and pathological range of height variation within as well as between human populations, and today, it

SUBMITTER: Muthuirulan P 

PROVIDER: S-EPMC6819265 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature