A deconvolution algorithm for multi-echo functional MRI: Multi-echo Sparse Paradigm Free Mapping.

ABSTRACT: This work introduces a novel algorithm for deconvolution of the BOLD signal in multi-echo fMRI data: Multi-echo Sparse Paradigm Free Mapping (ME-SPFM). Assuming a linear dependence of the BOLD percent signal change on the echo time (TE) and using sparsity-promoting regularized least squares estimation, ME-SPFM yields voxelwise time-varying estimates of the changes in the apparent transverse relaxation (ΔR₂^⁎) without prior knowledge of the timings of individual BOLD events. Our results in multi-echo fMRI data collected during a multi-task event-related paradigm at 3 Tesla demonstrate that the maps of R₂^⁎ changes obtained with ME-SPFM at the times of the stimulus trials show high spatial and temporal concordance with the activation maps and BOLD si

SUBMITTER: Caballero-Gaudes C 

PROVIDER: S-EPMC6819276 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature