Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer.

ABSTRACT:

Background

Given that breast cancer and normal dense fibroglandular tissue have similar radiographic attenuation, we examine whether automated volumetric density measures identify a differential change between breasts in women with cancer and compare to healthy controls.

Methods

Eligible cases (n = 1160) had unilateral invasive breast cancer and bilateral full-field digital mammograms (FFDMs) at two time points: within 2 months and 1-5 years before diagnosis. Controls (n = 2360) were matched to cases on age and date of FFDMs. Dense volume (DV) and volumetric percent density (VPD) for each breast were assessed using Volpara™. Differences in DV and VPD between mammograms (median 3 years apart) were calculated per breast separately for cases and controls and their difference ev

SUBMITTER: Brandt KR 

PROVIDER: S-EPMC6819393 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature