Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases.

ABSTRACT:

Background

Breast cancer (BC) is the most frequent malignant tumor in females and the 2nd most common cause of brain metastasis (BM), that are associated with a fatal prognosis. The increasing incidence from 10% up to 40% is due to more effective treatments of extracerebral sites with improved prognosis and increasing use of MRI in diagnostics. A frequently administered, potent chemotherapeutic group of drugs for BC treatment are taxanes usually used in the adjuvant and metastatic setting, which, however, have been suspected to be associated with a higher incidence of BM. The aim of our study was to experimentally analyze the impact of the taxane docetaxel (DTX) on brain metastasis formation, and to elucidate the underlying molecular mechanism.

Methods

A monocentric patient

SUBMITTER: Bernatz S 

PROVIDER: S-EPMC6819416 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature