Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells.

ABSTRACT: Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery system with the potential to improve the therapeutic efficacy of the treatment of a variety of disorders. As the incidence of breast cancer continues to rise, radiotherapy has emerged as a leading treatment modality. Radiotherapy also increases the risk of coronary heart disease and cardiac mortality. In a chest-irradiated mouse model of cardiac injury, we investigated the effects of local irradiation. We found an increased lethality after 16 Gy irradiation. Importantly, radio-detoxified LPS (RD-LPS) treatment prolonged the survival significantly. By flow cytometry, we demonstrated that u

SUBMITTER: Hegyesi H 

PROVIDER: S-EPMC6819448 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature