Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes.

ABSTRACT:

Background

The role of tumor-infiltrating B-cells (TIBs) and intratumorally-produced antibodies in cancer-immunity interactions essentially remains terra incognita. In particular, it remains unexplored how driver mutations could be associated with distinct TIBs signatures and their role in tumor microenvironment.

Methods

Here we analyzed associations of immunoglobulin isotypes and clonality with survival in TCGA RNA-Seq data for lung adenocarcinoma (LUAD), stratifying patients into 12 driver mutation and phenotypic tumor subgroups.

Results

We revealed several unexpected associations between TIBs behavior and prognosis. Abundance and high proportion of IgG1 isotype, and low proportion of IgA among all intratumorally produced immunoglobulins were specifically associated

SUBMITTER: Isaeva OI 

PROVIDER: S-EPMC6819482 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature