RACS: rapid analysis of ChIP-Seq data for contig based genomes.

ABSTRACT:

Background

Chromatin immunoprecipitation coupled to next generation sequencing (ChIP-Seq) is a widely-used molecular method to investigate the function of chromatin-related proteins by identifying their associated DNA sequences on a genomic scale. ChIP-Seq generates large quantities of data that is difficult to process and analyze, particularly for organisms with a contig-based sequenced genomes that typically have minimal annotation on their associated set of genes other than their associated coordinates primarily predicted by gene finding programs. Poorly annotated genome sequence makes comprehensive analysis of ChIP-Seq data difficult and as such standardized analysis pipelines are lacking.

Results

We present a one-stop computational pipeline, "Rapid Analysis of ChIP-Seq

SUBMITTER: Saettone A 

PROVIDER: S-EPMC6819487 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature