Bacitracin resistance and enhanced virulence of Streptococcus suis via a novel efflux pump.

ABSTRACT:

Background

Streptococcus suis is a prominent pathogen causing septicemia and meningitis in swine and humans. Bacitracin is used widely as a growth promoter in animal feed and to control the spread of necrotic enteritis in most developing countries. This study aimed to characterize a novel membrane transporter module Sst comprising SstE, SstF, and SstG for bacitracin resistance.

Results

Comparative genomics and protein homology analysis found a potential efflux pump SstFEG encoded upstream of well-known bacitracin-resistance genes bceAB and bceRS. A four-fold decrease in bacitracin susceptibility was observed in sstFEG deletion mutant comparing with S. suis wildtype strain CZ130302. Further studies indicated that the bacitracin tolerance mediated by SstFEG is not only indepen

SUBMITTER: Ma J 

PROVIDER: S-EPMC6819616 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature