Inflammatory responses to a pathogenic West Nile virus strain.

ABSTRACT:

Background

West Nile virus (WNV) circulates across Australia and was referred to historically as Kunjin virus (WNV_KUN). WNV_KUN has been considered more benign than other WNV strains circulating globally. In 2011, a more virulent form of the virus emerged during an outbreak of equine arboviral disease in Australia.

Methods

To better understand the emergence of this virulent phenotype and the mechanism by which pathogenicity is manifested in its host, cells were infected with either the virulent strain (NSW2012), or less pathogenic historical isolates, and their innate immune responses compared by digital immune gene expression profiling. Two different cell systems were used: a neuroblastoma cell line (SK-N-SH cells) and neuronal cells derived from induce

SUBMITTER: Huang B 

PROVIDER: S-EPMC6819652 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature