Population genetic variations of the MMP3 gene revealed hypoxia adaptation in domesticated yaks (Bos grunniens).

ABSTRACT:

Objective

As an iconic symbol of Qinghai-Tibetan Plateau and of high altitude, yak is subjected to hypoxic conditions that challenge aerobic metabolism. Matrix metalloproteinases-3 (MMP3) is assumed to be a key target gene of hypoxia-inducible factor-1α (HIF-1α) that function as a master regulator of the cellular response to hypoxia. Therefore, the aim of this investigation was to identify the DNA polymorphism of MMP3 gene in domestic yak and to explore its possible association with high-altitude adaptation.

Methods

The single-nucleotide polymorphisms (SNPs) genotyping and mutations scanning at the MMP3 locus were conducted in total of 344 individuals from four domestic Chinese yak breeds resident at different altitudes on the Qinghai-Tibetan Plateau, using high-resolution m

SUBMITTER: Ding X 

PROVIDER: S-EPMC6819682 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature