Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis.

ABSTRACT: Importance:Biphasic anaphylaxis may occur in up to 20% of patients with anaphylaxis; however, the optimal observation time of patients with resolved anaphylaxis is unknown. Objective:To characterize the cost-effectiveness of short vs prolonged medical observation times after resolved anaphylaxis. Design, Setting, and Participants:An economic evaluation was performed of computer-simulated adult patients observed in outpatient allergy clinics and emergency departments, with rates of biphasic anaphylaxis derived from a 2019 meta-analysis. Exposures:Computer-simulated patients (10 000 per strategy) were randomized to undergo 1 hour of medical observation (associated with 95% negative predictive value of biphasic anaphylaxis) or 6 or more hours of observation (associated with a 97.3% negative p

SUBMITTER: Shaker M 

PROVIDER: S-EPMC6820064 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature