A systematic genotype and subgenotype re-ranking of hepatitis B virus under a novel classification standard.

ABSTRACT:

Background and aim

It is commonly noticed that chaotic and inefficient subgenotyping are universally used academically and clinically, a standardized HBV genotype/subgenotype classification criterion is urgently acquired. Sequence similarity, which was commonly used for the last three decades, should be upgraded by phylogenetic analysis in genotyping of recombinant-free HBV strains.

Methods

In this study, 4,429 HBV whole-genome sequences were employed to reconstruct the phylogeny of HBV using Bayesian inference. After excluding recombinant sequences, calculating partitioned evolutionary models, excluding recombinant sequences, reconstructing phylogenetic trees, and performing a correlation analysis of genetic distances, geographical distribution and serotypes, we systematica

SUBMITTER: Yin Y 

PROVIDER: S-EPMC6820102 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature