Sugary beverage intake and preclinical Alzheimer's disease in the community.

ABSTRACT:

Introduction

Excess sugar consumption has been linked with Alzheimer's disease (AD) pathology in animal models.

Methods

We examined the cross-sectional association of sugary beverage consumption with neuropsychological (N = 4276) and magnetic resonance imaging (N = 3846) markers of preclinical Alzheimer's disease and vascular brain injury (VBI) in the community-based Framingham Heart Study. Intake of sugary beverages was estimated using a food frequency questionnaire.

Results

Relative to consuming less than one sugary beverage per day, higher intake of sugary beverages was associated with lower total brain volume (1-2/day, β ± standard error [SE] = -0.55 ± 0.14 mean percent difference, P = .0002; >2/day, β ± SE = -0.68 ± 0.18, P < .0001), and poorer performance on tes

SUBMITTER: Pase MP 

PROVIDER: S-EPMC6820519 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature