Uterine SOX17: a key player in human endometrial receptivity and embryo implantation.

ABSTRACT: The yin and yang of female fertility is a complicated issue; large numbers of women/couples desire fertility and seek assisted reproduction intervention to achieve conception, while others seek to prevent pregnancy. Understanding specific molecules which control endometrial-embryo interactions is essential for both facilitating and preventing pregnancy. SOX17 has recently emerged as an important transcription factor involved in endometrial receptivity and embryo implantation. However, studies to date have examined mouse models of pregnancy which do not necessarily translate to the human. Demonstration of a role for 'implantation factors' in a human system is critical to provide a rationale for in depth clinical investigation and targeting of such factors. We demonstrate that SOX17is presen

SUBMITTER: Kinnear S 

PROVIDER: S-EPMC6820561 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature