Oxandrolone for growth hormone-treated girls aged up to 18 years with Turner syndrome.

ABSTRACT:

Background

The final adult height of untreated girls aged up to 18 years with Turner syndrome (TS) is approximately 20 cm shorter compared with healthy females. Treatment with growth hormone (GH) increases the adult height of people with TS. The effects of adding the androgen, oxandrolone, in addition to GH are unclear. Therefore, we conducted this systematic review to investigate the benefits and harms of oxandrolone as an adjuvant therapy for people with TS treated with GH.

Objectives

To assess the effects of oxandrolone on growth hormone-treated girls aged up to 18 years with Turner syndrome.

Search methods

We searched CENTRAL, MEDLINE, Embase, the ICTRP Search Portal and ClinicalTrials.gov. The date of the last search was October 2018. We applied no language restr

SUBMITTER: Mohamed S 

PROVIDER: S-EPMC6820693 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature