Leu⁸ and Pro⁸ oxytocin agonism differs across human, macaque, and marmoset vasopressin 1a receptors.

ABSTRACT: Oxytocin (OXT) is an important neuromodulator of social behaviors via activation of both oxytocin receptors (OXTR) and vasopressin (AVP) 1a receptors (AVPR1a). Marmosets are neotropical primates with a modified OXT ligand (Pro⁸-OXT), and this ligand shows significant coevolution with traits including social monogamy and litter size. Pro⁸-OXT produces more potent and efficacious responses at primate OXTR and stronger behavioral effects than the consensus mammalian OXT ligand (Leu⁸-OXT). Here, we tested whether OXT/AVP ligands show differential levels of crosstalk at primate AVPR1a. We measured binding affinities and Ca²⁺ signaling responses of AVP, Pro⁸-OXT and Leu⁸-OXT at human, macaque, and marmoset AVPR1a. We found that AV

SUBMITTER: Mustoe A 

PROVIDER: S-EPMC6820730 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature