Transcriptomic profile of cystic fibrosis airway epithelial cells undergoing repair.

ABSTRACT: Pathological remodeling of the airway epithelium is commonly observed in Cystic Fibrosis (CF). The different cell types that constitute the airway epithelium are regenerated upon injury to restore integrity and maintenance of the epithelium barrier function. The molecular signature of tissue repair in CF airway epithelial cells has, however, not well been investigated in primary cultures. We therefore collected RNA-seq data from well-differentiated primary cultures of bronchial human airway epithelial cells (HAECs) of CF (F508del/F508del) and non-CF (NCF) origins before and after mechanical wounding, exposed or not to flagellin. We identified the expression changes with time of repair of genes, the products of which are markers of the different cell types that constitute the airway epithel

SUBMITTER: Zoso A 

PROVIDER: S-EPMC6820749 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature