Early diagnosis of colorectal cancer via plasma proteomic analysis of CRC and advanced adenomatous polyp.

ABSTRACT:

Aim

This paper aimed to identify new candidate biomarkers in blood for early diagnosis of CRC.

Background

Colorectal cancer (CRC) is the third most widespread malignancies increasing globally. The high mortality rate associated with colorectal cancer is due to the delayed diagnosis in an advanced stage while the metastasis has occurred. For better clinical management and subsequently to reduce mortality of CRC, early detection biomarkers are in high demand.

Methods

A 2D-PAGE separation of proteins was performed followed by tandem mass Spectrometry (MALDI-TOF-TOF) to discover potential plasma protein markers for CRC and AA (advanced adenomas). Furthermore, western blot method was used to confirm a part of the results in colorectal tissue samples.

Results

The sig

SUBMITTER: Fayazfar S 

PROVIDER: S-EPMC6820836 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature