Evaluation of long-term course in children with eosinophilic esophagitis reveals distinct histologic patterns and clinical characteristics.

ABSTRACT: BACKGROUND:Eosinophilic esophagitis (EoE) is a chronic and increasingly prevalent antigen-driven disease. There is a paucity of information on long-term course in children. OBJECTIVE:We sought to understand the longitudinal trajectory of pediatric EoE during routine clinical care. METHODS:We prospectively enrolled children into an EoE database and reviewed their medical and pathologic records over 13 years. RESULTS:From 2011 to 2015, 146 children with EoE seen for their first visit at our center had 2 or more years of follow-up and 3 or more endoscopies over an average follow-up period of 5.13 years (range, 2-13 years). Longitudinal eosinophilic inflammation during treatment demonstrated 3 patterns over time. Children with less than 15 eosinophils/high-power field (hpf) for greater than 75

SUBMITTER: Collins CA 

PROVIDER: S-EPMC6820855 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature