RNA Helicase LGP2 Negatively Regulates RIG-I Signaling by Preventing TRIM25-Mediated Caspase Activation and Recruitment Domain Ubiquitination.

ABSTRACT: The retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are a family of cytosolic pattern recognition receptors that play a critical role in binding viral RNA and triggering antiviral immune responses. The RLR LGP2 (or DHX58) is a known regulator of the RIG-I signaling pathway; however, the underlying mechanism by which LGP2 regulates RIG-I signaling is poorly understood. To better understand the effects of LGP2 on RIG-I-specific signaling and myeloid cell responses, we probed RIG-I signaling using a highly specific RIG-I agonist to compare transcriptional profiles between WT and Dhx58^-/- C57BL\6 bone marrow-derived dendritic cells. Dhx58^-/- cells exhibited a marked increase in the magnitude and kinetics of type I interferon (IFN) induction and

SUBMITTER: Quicke KM 

PROVIDER: S-EPMC6820871 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature