Glycemia affects glomerular filtration rate in people with type 2 diabetes.

ABSTRACT:

Background

In type 2 diabetes (T2DM), the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimated glomerular filtration rate (eGFR) systematically underestimates the measured adjusted glomerular filtration rate (aGFR) when aGFR is high. We studied the extent to which glycemic variables associate with kidney function, and developed equations including these variables that estimate aGFR in people with T2DM.

Methods

Diabetic Pima people had aGFR measured from iothalamate clearance divided by body surface area. eGFRs < 60 ml/min/1.73m² were excluded. Multivariate linear regression identified variables correlated with kidney function. We constructed equations for approximating aGFR. Correlation analysis and 10-fold cross-validation were used

SUBMITTER: Weil EJ 

PROVIDER: S-EPMC6820937 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature