Ontology highlight
ABSTRACT:
SUBMITTER: Yu D
PROVIDER: S-EPMC6820997 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Cell reports 20191001 1
Calorie restriction (CR) extends the healthspan and lifespan of diverse species. In mammals, a broadly conserved metabolic effect of CR is improved insulin sensitivity, which may mediate the beneficial effects of a CR diet. This model has been challenged by the identification of interventions that extend lifespan and healthspan yet promote insulin resistance. These include rapamycin, which extends mouse lifespan yet induces insulin resistance by disrupting mTORC2 (mechanistic target of rapamycin ...[more]