Role of mitochondria and cardiolipins in growth inhibition of breast cancer cells by retinoic acid.

ABSTRACT:

Background

All-trans-retinoic-acid (ATRA) is a promising agent in the prevention/treatment of breast-cancer. There is growing evidence that reprogramming of cellular lipid metabolism contributes to malignant transformation and progression. Lipid metabolism is implicated in cell differentiation and metastatic colonization and it is involved in the mechanisms of sensitivity/resistance to different anti-tumor agents. The role played by lipids in the anti-tumor activity of ATRA has never been studied.

Methods

We used 16 breast cancer cell-lines whose degree of sensitivity to the anti-proliferative action of ATRA is known. We implemented a non-oriented mass-spectrometry based approach to define the lipidomic profiles of each cell-line grown under basal conditions and following tr

SUBMITTER: Terao M 

PROVIDER: S-EPMC6821005 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature