A metabolic reconstruction of Lactobacillus reuteri JCM 1112 and analysis of its potential as a cell factory.

ABSTRACT:

Background

Lactobacillus reuteri is a heterofermentative Lactic Acid Bacterium (LAB) that is commonly used for food fermentations and probiotic purposes. Due to its robust properties, it is also increasingly considered for use as a cell factory. It produces several industrially important compounds such as 1,3-propanediol and reuterin natively, but for cell factory purposes, developing improved strategies for engineering and fermentation optimization is crucial. Genome-scale metabolic models can be highly beneficial in guiding rational metabolic engineering. Reconstructing a reliable and a quantitatively accurate metabolic model requires extensive manual curation and incorporation of experimental data.

Results

A genome-scale metabolic model of L. reuteri JCM 1112^T

SUBMITTER: Kristjansdottir T 

PROVIDER: S-EPMC6821008 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature