Gene expression profiling in blood from cerebral malaria patients and mild malaria patients living in Senegal.

ABSTRACT:

Background

Plasmodium falciparum malaria remains a major health problem in Africa. The mechanisms of pathogenesis are not fully understood. Transcriptomic studies may provide new insights into molecular pathways involved in the severe form of the disease.

Methods

Blood transcriptional levels were assessed in patients with cerebral malaria, non-cerebral malaria, or mild malaria by using microarray technology to look for gene expression profiles associated with clinical status. Multi-way ANOVA was used to extract differentially expressed genes. Network and pathways analyses were used to detect enrichment for biological pathways.

Results

We identified a set of 443 genes that were differentially expressed in the three patient groups after applying a false discovery rate o

SUBMITTER: Thiam A 

PROVIDER: S-EPMC6821028 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature