Combining prostate cancer radiotherapy with therapies targeting the androgen receptor axis.

ABSTRACT:

Background

Prostate cancer (pca) is the most common non-dermatologic cancer and the 3rd leading cause of male cancer mortality in Canada. In patients with high-risk localized or recurrent pca, management typically includes the combination of long-term androgen deprivation therapy (adt) and radiotherapy (rt). New androgen-receptor-axis targeted therapies (arats), which await validation, offer an option to intensify therapy.

Methods

In this narrative review, we report the relevant history that has supported combining adt with rt. The literature in PubMed was searched for studies involving pca and novel arats (abiraterone acetate, enzalutamide, apalutamide, darolutamide) published between 1995 and 2019. Literature discussing clinical trials in which those modalities were combin

SUBMITTER: Ghashghaei M 

PROVIDER: S-EPMC6821115 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature