RNA-align: quick and accurate alignment of RNA 3D structures based on size-independent TM-scoreRNA.

ABSTRACT:

Motivation

Comparison of RNA 3D structures can be used to infer functional relationship of RNA molecules. Most of the current RNA structure alignment programs are built on size-dependent scales, which complicate the interpretation of structure and functional relations. Meanwhile, the low speed prevents the programs from being applied to large-scale RNA structural database search.

Results

We developed an open-source algorithm, RNA-align, for RNA 3D structure alignment which has the structure similarity scaled by a size-independent and statistically interpretable scoring metric. Large-scale benchmark tests show that RNA-align significantly outperforms other state-of-the-art programs in both alignment accuracy and running speed. The major advantage of RNA-align lies at the quic

SUBMITTER: Gong S 

PROVIDER: S-EPMC6821192 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature