Dopaminergic medication reduces striatal sensitivity to negative outcomes in Parkinson's disease.

ABSTRACT: Reduced levels of dopamine in Parkinson's disease contribute to changes in learning, resulting from the loss of midbrain neurons that transmit a dopaminergic teaching signal to the striatum. Dopamine medication used by patients with Parkinson's disease has previously been linked to behavioural changes during learning as well as to adjustments in value-based decision-making after learning. To date, however, little is known about the specific relationship between dopaminergic medication-driven differences during learning and subsequent changes in approach/avoidance tendencies in individual patients. Twenty-four Parkinson's disease patients ON and OFF dopaminergic medication and 24 healthy controls subjects underwent functional MRI while performing a probabilistic reinforcement learning exper

SUBMITTER: McCoy B 

PROVIDER: S-EPMC6821230 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature