Interictal epileptiform discharges shape large-scale intercortical communication.

ABSTRACT: Dynamic interactions between remote but functionally specialized brain regions enable complex information processing. This intercortical communication is disrupted in the neural networks of patients with focal epilepsy, and epileptic activity can exert widespread effects within the brain. Using large-scale human intracranial electroencephalography recordings, we show that interictal epileptiform discharges (IEDs) are significantly coupled with spindles in discrete, individualized brain regions outside of the epileptic network. We found that a substantial proportion of these localized spindles travel across the cortical surface. Brain regions that participate in this IED-driven oscillatory coupling express spindles that have a broader spatial extent and higher tendency to propagate than spi

SUBMITTER: Dahal P 

PROVIDER: S-EPMC6821283 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature