Associations of early life and adulthood adiposity with risk of epithelial ovarian cancer.

ABSTRACT:

Background

Few studies have evaluated the association between early life adiposity and ovarian cancer risk. Adiposity during different periods of life may be differentially associated with the risk.

Patients and methods

We prospectively followed 133 526 women in the Nurses' Health Study (NHS; 1980-2012) and NHSII (1989-2013). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident ovarian cancer (N = 788) according to validated measures for early life adiposity [body mass index (BMI) at age 10 imputed from somatotype and recalled BMI at age 18) as well as BMI change between age 10 and 18 and after age 18 (current weight assessed on every biennial questionnaire since baseline).

Results

After mutual adjus

SUBMITTER: Huang T 

PROVIDER: S-EPMC6821311 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature