MultiPhATE: bioinformatics pipeline for functional annotation of phage isolates.

ABSTRACT:

Summary

To address the need for improved phage annotation tools that scale, we created an automated throughput annotation pipeline: multiple-genome Phage Annotation Toolkit and Evaluator (multiPhATE). multiPhATE is a throughput pipeline driver that invokes an annotation pipeline (PhATE) across a user-specified set of phage genomes. This tool incorporates a de novo phage gene calling algorithm and assigns putative functions to gene calls using protein-, virus- and phage-centric databases. multiPhATE's modular construction allows the user to implement all or any portion of the analyses by acquiring local instances of the desired databases and specifying the desired analyses in a configuration file. We demonstrate multiPhATE by annotating two newly sequenced Yersinia pestis phage geno

SUBMITTER: Ecale Zhou CL 

PROVIDER: S-EPMC6821344 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature