Evaluating Chromatin Accessibility Differences Across Multiple Primate Species Using a Joint Modeling Approach.

ABSTRACT: Changes in transcriptional regulation are thought to be a major contributor to the evolution of phenotypic traits, but the contribution of changes in chromatin accessibility to the evolution of gene expression remains almost entirely unknown. To address this important gap in knowledge, we developed a new method to identify DNase I Hypersensitive (DHS) sites with differential chromatin accessibility between species using a joint modeling approach. Our method overcomes several limitations inherent to conventional threshold-based pairwise comparisons that become increasingly apparent as the number of species analyzed rises. Our approach employs a single quantitative test which is more sensitive than existing pairwise methods. To illustrate, we applied our joint approach to DHS sites in fibrob

SUBMITTER: Edsall LE 

PROVIDER: S-EPMC6821351 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature