A Bayesian model integration for mutation calling through data partitioning.

ABSTRACT: MOTIVATION:Detection of somatic mutations from tumor and matched normal sequencing data has become among the most important analysis methods in cancer research. Some existing mutation callers have focused on additional information, e.g. heterozygous single-nucleotide polymorphisms (SNPs) nearby mutation candidates or overlapping paired-end read information. However, existing methods cannot take multiple information sources into account simultaneously. Existing Bayesian hierarchical model-based methods construct two generative models, the tumor model and error model, and limited information sources have been modeled. RESULTS:We proposed a Bayesian model integration framework named as partitioning-based model integration. In this framework, through introducing partitions for paired-end reads

SUBMITTER: Moriyama T 

PROVIDER: S-EPMC6821361 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature