Formate concentrations in maternal plasma during pregnancy and in cord blood in a cohort of pregnant Canadian women: relations to genetic polymorphisms and plasma metabolites.

ABSTRACT:

Background

One-carbon metabolism, responsible for purine and thymidylate synthesis and transmethylation reactions, plays a critical role in embryonic and fetal development. Formate is a key player in one-carbon metabolism. In contrast to other one-carbon metabolites, it is not linked to tetrahydrofolate, is present in plasma at appreciable concentrations, and may therefore be distributed to different tissues.

Objective

The study was designed to determine the concentration of formate in cord blood in comparison with maternal blood taken earlier in pregnancy and at delivery and to relate formate concentrations to potential precursors and key fetal genotypes.

Methods

Formate and amino acids were measured in plasma during early pregnancy (12-16 wk), at delivery (37-42 wk)

SUBMITTER: Brosnan JT 

PROVIDER: S-EPMC6821548 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature